Inkcazelo emfutshane:
Inombolo yeCAS: 59-05-2
Ifomula yemolekyuli:C20H22N8O5
ubunzima bemolekyuli: 454.45
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | I-Methotrexate |
| IBanga | ibakala lamayeza |
| Imbonakalo | i-orenji-yellow crystalline powder. |
| Isivavanyi | 99% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/ibhokisi |
| Uphawu | Izinzile, kodwa ilula kwaye i-hygroscopic. Ayihambelani ne-acids eqinile, i-oxidizing agents ezinamandla. |
| Imeko | Gcina kwindawo emnyama, umoya ongangeni, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C |
Yintoni iMethotrexate?
I-Methotrexate inomdla kwi-hydrolysis, i-oxidation kunye nokukhanya. Ayinyibiliki emanzini. I-Methotrexate ibola kwiimeko ze-acidic kakhulu okanye i-alkaline. I-Methotrexate ayihambelani ne-oxidizing agents ezinamandla kunye ne-acids eqinile.
I-Methotrexate lichiza elisetyenziselwa ukunyanga umhlaza, owaziwa ngokuba ngamachiza e-cytotoxic. Ukuze kuncitshiswe i-cytotoxicity, ingasetyenziswa kunye ne-calcium leucovorin. Isetyenziselwa ikakhulu kunyango lwe-acute leukemia (i-acute lymphocytic leukemia), umhlaza webele, imolekyuli enobungozi kunye ne-choriocarcinoma, umhlaza wentloko kunye nentamo, umhlaza wethambo, i-leukemia, ukungena kwe-meningeal ye-spinal cord, umhlaza wemiphunga, umhlaza wenkqubo yokuzala, umhlaza wesibindi, i-refractory. i-psoriasis vulgaris, i-dermatomyositis, i-myositis yomzimba, i-ankylosing spondylitis ukudumba, isifo sikaCrohn, i-psoriasis kunye ne-psoriatic arthritis, isifo sikaBehcet kunye nesifo somzimba. I-Methotrexate yi-immuno suppressant kwaye ingasetyenziselwa ukunciphisa inkqubo ye-rheumatism kunye nokusebenza okugqwesileyo ngokukodwa ekunyangeni ukudumba kwe-synovial ye-rheumatoid arthritis kwaye lelona ziyobisi lisetyenziswa rhoqo ukunyanga izifo zamathambo.
Isicelo seklinikhi
Iyasebenza ekunyangeni i-acute leukemia ngokusebenza ngcono kwizigulana zabantwana. Inokusebenza kakuhle ekuphatheni i-choriocarcinoma kunye ne-moles enobungozi. Ulawulo lwedosi enkulu luyasebenza ekunyangeni i-osteosarcoma, i-sarcoma yezicubu ezithambileyo, umhlaza wemiphunga, umhlaza wamatyhalarha, umhlaza wamabele, kunye nomhlaza wesibeleko. Ikwasebenza ekunyangeni umhlaza wentloko kunye nentamo, umhlaza wesibindi kunye nomhlaza wesisu. I-Arterial infusion yale mveliso ine-goo efficacy ekunyangeni umhlaza wentloko kunye nentamo kunye nomhlaza wesibindi. Nangona kunjalo, ayifane isetyenziswe ukunyanga i-psoriasis kunye ne-psoriasis.
