Inkcazelo emfutshane:
Inombolo yeCAS: 69004-03-1
Ifomula yemolekyuli:C18H14F3N3O4S
ubunzima bemolekyuli: 425.38
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | I-Toltrazuril |
| Inombolo yeCAS. | 69004-03-1 |
| Umbala | Umgubo omhlophe okanye ophantse umhlophe wekristale |
| IBanga | Yondla iBanga |
| Ugcino | Itywinwe kwindawo eyomileyo, yoBubushushu beGumbi |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Sebenzisa | Iinkomo, Inkukhu, Inja, Intlanzi, Ihashe, Ihagu |
| Iphakheji | 25kg/igubu |
Inkcazo
I-Toltrazuril (Baycox®,Procox®) lichiza le-triazinon elithatha i-anticoccidial ebanzi kunye ne-antiprotozoalactivity. Ayifumaneki kwezorhwebo e-United States, kodwa iyafumaneka nakwamanye amazwe. Isebenza ngokuchasene nenqanaba le-asexual kunye nesondo le-coccidia ngokuthintela ulwahlulo lwenyukliya lwe-schizonts kunye ne-microga-monts kunye nemizimba eyenza udonga lwe-macrogamonts. Inokuba luncedo kunyango lwe-porcinecoccidiosis ye-neonatal, i-EPM, kunye ne-canine hepatozoonosis.
I-Toltrazuril kunye ne-metabolite yayo enkulu i-ponazuril (i-toltrazuril sulfone, i-Marquis) ngamachiza e-antiprotozoal asekwe kwi-triazine anomsebenzi othile ngokuchasene nosulelo lwe-apicomplexan coccidial. I-Toltrazuril ayifumaneki e-United States.
Ukusetyenziswa kwemveliso
Ihagu: I-Toltrazuril ibonakaliswe ukuba yehlisa iimpawu ze-coccidiosis kwiihagu zokonga ezosulelekileyo ngokwendalo xa i-20–30 mg/kg yomlomo enye i-BWdose inikwa iihagu ezi-3 ukuya kwezi-6 (Driesen et al., 1995). Iimpawu zeklinikhi zancitshiswa ukusuka kwi-71 ukuya kwi-22% yeehagu ezincancisayo, kwaye urhudo kunye ne-oocyst excretion nayo yancitshiswa ngonyango olulodwa lomlomo. Iimveliso ezivunyiweyo zithatha ixesha leentsuku ezingama-77 eUnited Kingdom.
Amathole kunye namatakane: I-Toltrazuril isetyenziselwa uthintelo lweempawu zeklinikhi ze-coccidiosis kunye nokunciphisa ukuchithwa kwe-coccidia kumathole kunye namatakane njengonyango lwedosi enye. Amaxesha okurhoxa e-United Kingdom yi-63 kunye neentsuku ezingama-42 zamathole kunye namatakane, ngokulandelelanayo.
Izinja: Kwi-hepatozoonosis, i-toltrazuril inikwe ngomlomo kwi-5 mg / kg ye-BW rhoqo kwiiyure ze-12 ngeentsuku ze-5 okanye inikwe ngomlomo kwi-10 mg / kg ye-BW nganye kwiiyure ze-12 kwiintsuku ze-10 ibangele ukuxolelwa kweempawu zeklinikhi kwizinja ezisulelekileyo ngokwendalo kwiintsuku ze-2-3. Macintire et al., 2001). Ngelishwa, izinja ezininzi ezinyangwayo ziye zaphinda zaphinda zafa ngenxa ye-hepatozoonosis. Kwiinjana ezine-Isospora sp. usulelo, unyango nge-0.45 mg emodepside zidityaniswe ne-9 mg/kg ye-BW toltrazuril (i-Procox®, i-Bayer Animal Health) yehlisa i-oocyst count nge-91.5–100%. Kwakungekho mmahluko kwixesha lohudo xa unyango luqalisiwe emva kokuqala kweempawu zeklinikhi ngexesha losulelo lwe-patent (Altreuther et al., 2011).
Iikati: Kumantshontsho ekati osulelwe ngomfuniselo we-Isospora spp., unyango ngedosi yomlomo enye ye-0.9 mg emodepside zidityaniswe ne-18 mg/kg ye-BW toltrazuril (Procox®, Bayer AnimalHealth) kunciphisa ukuphalala kwe-oocyst ngama-96.7–100% ukuba kunikwe ngexesha lokumiselwa kwangaphambili. ixesha (uPetry et al., 2011).
Amahashe: I-Toltrazuril iye yasetyenziselwa unyango lwe-EPM. Eli chiza likhuselekile, nakumadosi aphezulu. Unyango olucetyiswayo lwangoku luyi-5-10 mg / kg ngomlomo kwiintsuku ezingama-28. Ngaphandle kokusebenza kakuhle kwe-toltrazuril, ukusetyenziswa kwayo kwehlile emahasheni ngenxa yokufumaneka okungcono kwamanye amachiza asebenzayo.
