Inkcazelo emfutshane:
Inombolo yeCAS: 1264-72-8
Ifomula yemolekyuli:2(C52H98N16O13).5(H2SO4)
ubunzima bemolekyuli: 2801.27
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Colistin sulfate |
| IBanga | Yondla iBanga |
| Imbonakalo | Imhlophe okanye iphantse imhlophe, i-hygroscopic powder |
| Isivavanyi | 99% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 20kg/ibhokisi 20kg/igubu |
| Imeko | Gcina kwi -20 ℃ unyaka omnye (Powder) |
Inkcazo yemveliso
I-Colistin yi-cyclic cationic decapeptide edityaniswe kwikhonkco le-asidi enamafutha, liqela leepeptides ezilwa ne-antimicrobial ezicwangcisiweyo ezifanayo.I-Colistin sulfate yi-antibiotic ye-polypeptide evimbela iibhaktheriya zegram-negative ngokuzibophelela kwi-lipopolysaccharides kunye ne-phospholipids kwi-membrane yeseli yangaphandle ye-bacteria yegram-negative.
I-Colistin sulfate, eyaziwa ngokuba yi-colistin sulfate, iChristian (Colistin), iPolymyxin E (Polymyxin E), i-antiphytin, imhlophe okanye iphantse ibe mhlophe ngumgubo, ayinavumba, incasa ekrakrayo ukufuma, inyibilika ngokulula emanzini, inyibilika kancinane kwi-methanol, i-ethanol, phantse ayinyibiliki kuyo. Iacetone, i-ether, ialkali yasimahla inyibilika kancinane emanzini.Izinzile kwi-PH3-7.5 uluhlu.I-Mycolistin sulfate iveliswa yi-Bacillus polymyxoides, enefuthe elinamandla lokulwa ne-antibacterial kwiibhaktheriya zegram-negative.Isetyenziselwa ukunyanga izifo zamathumbu ezibangelwa yintsholongwane yegram-negative, kwaye isetyenziswa njengesongezo sokutya kunye nesiphumo esicacileyo sokukhulisa ukukhula.Ukudibanisa kwe-sulfadiazine effect kungcono.
Umsebenzi wemveliso
I-Colistin sulfate granules iphuculwe ekuzinzeni kwamandla kwisondlo kunye nokubonisa ukunyibilika okuphezulu naphezu kokuveliswa kwayo ngaphandle kokusebenzisa nayiphi na i-carrier ebiza kakhulu okanye izixhobo ezikhethekileyo.Ngokukodwa, i-colistin sulfate granules ebandakanya i-colistin sulfate kwaye ine-particle diameters ye-150 ukuya kwi-1500m, indawo ethile ye-40 ukuya kwi-500 cm2 / g, ixesha lokumanzisa imizuzu emi-5 okanye ngaphantsi kunye nomxholo wokufuma we-10 % okanye ngaphantsi.
Pharmacodynamics
I-Colistin yi-agent ye-polymyxin ye-antibiotic.Iipolymyxins ziipolypeptides ze-cationic eziphazamisa inwebu yeseli yebhaktiriya ngendlela yokucoca.Ngokuphuhliswa kwee-agent ezinetyhefu encinci, ezifana ne-expenicillin-spectrum kunye ne-cephalosporins, ukusetyenziswa kwe-polymyxin ye-parenteral kwayekwa kakhulu, ngaphandle konyango losulelo lwemiphunga olunganyangekiyo ngamachiza kwizigulana ezine-cystic fibrosis.
