Inkcazelo emfutshane:
Inombolo yeCAS:51322-75-9
Ifomula yemolekyuli:C9H8ClN5S
ubunzima bemolekyuli:253.71
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Tizanidine |
| IBanga | Ibakala le-Pharma |
| Imbonakalo | Umgubo oMhlophe |
| Isivavanyi | 99% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/igubu |
| Imeko | Gcina kwi -20°C |
Ulwandlalo
I-Tizanidine yi-imidazoline ezimbini ze-nitrogen heterocyclic pentene derivative. Isakhiwo sifana neso se-clonidine. Kwi-1987, yaqala ukudweliswa eFinland njengombindi we-adrenalin α2 receptor agonist. Okwangoku, isetyenziswa njengesixhobo sokuphumla kwezihlunu ekliniki. Ingasetyenziselwa ukunyanga i-spasm ebuhlungu yemisipha, njenge-neck waist syndrome kunye ne-torticollis. Ingasetyenziselwa ukuphatha intlungu emva kokuhlinzwa, njenge-disc herniation kunye ne-hip arthritis. Ivela kwi-ankylosis yeengxaki ze-neurological, ezifana ne-multiple sclerosis, i-myelopathy engapheliyo, ingozi ye-cerebrovascular kunye njl.
Umsebenzi
Isetyenziselwa ukunciphisa uxinzelelo lwe-skeletal muscle, i-muscle spasm kunye ne-myotonia ebangelwa yingqondo kunye nokulimala kwentambo yomgogodla, i-cerebral hemorrhage, i-encephalitis kunye ne-multiple sclerosis.
I-Pharmacology
Ngokukhethayo iyanciphisa ukukhutshwa kwe-amino acids evuselelayo kwi-interneurons kwaye inqanda indlela ye-synaptic emininzi enxulumene nokugqithiswa kwemisipha. Le mveliso ayichaphazeli ukuhanjiswa kwe-neuromuscular. Inyamezeleka kakuhle. Iyasebenza kwizihlunu ezibuhlungu kakhulu kwaye i-ankylosis engapheliyo isuka kwintambo yomqolo kunye nengqondo. Inokunciphisa ukuchasana kwentshukumo ye-passive, ukunciphisa i-spasticity kunye ne-clonus, kunye nokwandisa ukuqina kokunyakaza ngokuzithandela.
Usebenzisa
Ibhalwe i-Tizanidine, ejoliswe ukusetyenziswa njengomgangatho wangaphakathi wokulinganisa i-Tizanidine nge-GC- okanye i-LC-mass spectrometry. I-Tizanidine inokuba nokusetyenziswa konyango njenge-SARS-CoV-2 engundoqo ye-protease inhibitor.
Ukusetyenziswa kweKlinikhi
I-Tizanidine yi-adrenergic α2 receptor agonist esebenza kwindawo esembindini esetyenziselwa ukunyanga iimeko ezingapheliyo ze-muscle spasticity, ezifana ne-multiple sclerosis.
Indlela yokwenza
I-Tizanidine yi-analogue epholileyo ye-muscle esebenzayo ye-clonidine evunyiweyo ukuba isetyenziswe ekunciphiseni i-spasticity ehambelana nokulimala kwe-cerebral okanye i-spinal cord. Indlela yokusebenza kwayo yokunciphisa i-spasticity iphakamisa ukuvinjelwa kwe-presynaptic ye-motor neuronsαI-2-adrenergic receptor sites, ukunciphisa ukukhutshwa kwe-amino acids evuselelayo kunye nokuthintela iindlela eziququzelelayo ze-ceruleospinal, ngaloo ndlela kubangele ukunciphisa i-spasticity. I-Tizanidine ineqhezu elincinci lesenzo se-antihypertensive se-clonidine, mhlawumbi ngenxa yesenzo kwiqela elikhethiweyo.αI-2C-adrenoceptors, ebonakala ngathi inoxanduva lomsebenzi we-analgesic kunye ne-antispasmodic. imidazolineαI-2-agonists (20).
