Inkcazelo emfutshane:
Inombolo ye-CAS: 58-55-9
Ifomula yemolekyuli: C7H8N4O2
Ubunzima bemolekyuli:180.16
Ubume bekhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Theophylline Anhydrous |
| Inombolo yeCAS. | 58-55-9 |
| Imbonakalo | mhlophe ukuya kokukhanya kwekristale pow etyhelider |
| Uzinzo: | Izinzile. Ayihambelani ne-oxidizing agents ezinamandla. |
| Ukunyibilika kwamanzi | 8.3 g/L (20 ºC) |
| Ugcino | 2-8°C |
| Beka ubomi kwishelufa | 2 Yiindlebe |
| Iphakheji | 25kg/Igubu |
Ingcaciso yeMveliso
I-Theophylline yi-methylxanthine esebenza njenge-bronchodilator ebuthathaka. Iluncedo kunyango olungapheliyo kwaye ayiloncedo kwi-exacerbations ebukhali.
I-Theophylline yi-methylxanthine alkaloid eyi-inhibitor ekhuphisanayo ye-phosphodiesterase (PDE; Ki = 100 μM). Kwakhona ngumchasi ongakhethiyo we-adenosine A receptors (Ki = 14 μM ye-A1 kunye ne-A2). I-Theophylline ibangela ukuphumla kwe-feline bronchiole muscle smooth precontracted ne-acetylcholine (EC40 = 117 μM; EC80 = 208 μM). Iifomyula eziqulethe i-theophylline zisetyenziswe kunyango lwe-asthma kunye nesifo esingapheliyo se-pulmonary obstructive (COPD).
Isicelo
1.Ukunyangwa kwe-asthma: I-Theophylline inokunceda ukunciphisa iimpawu ze-asthma ngokukhulula iipaseji ze-bronchial kunye nokwandisa ukuphumla kwemisipha.
2.Ukunyangwa kwesifo senhliziyo: I-Theophylline inokusebenza njenge-vasodilator, inceda ekuphuculeni iimpawu zesifo senhliziyo.
3.Ukukhuthazwa kwenkqubo ye-nervous central: I-Theophylline isetyenziswe kwamanye amayeza njengento evuselela inkqubo ye-nervous central, ukukhuthaza ukuphaphama kunye nokuqwalaselwa.
4.Ukulawulwa kwe-fat metabolism: I-Theophylline inokukhuthaza ukuchithwa kwamafutha kwaye kukholelwa ukuba luncedo ekulawuleni ubunzima kunye nokulahlekelwa kwesisindo.
