Inkcazelo emfutshane:
Inombolo ye-CAS: 1405-10-3
Ifomula yemolekyuli: C23H48N6O17S
Ubunzima bemolekyuli: 712.72
Ubume bekhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Neomycin sulfate |
| Inombolo yeCAS. | 1405-10-3 |
| Imbonakalo | Umgubo oMhlophe ukuya kumthubi kancinane |
| IBanga | Pharma iBanga |
| Ukunyibilika kwamanzi | Inyibilika emanzini |
| Ugcino | 2-8°C |
| Beka ubomi kwishelufa | 2 Yiindlebe |
| Iphakheji | 25kg/Igubu |
Ingcaciso yeMveliso
I-Neomycin sulfate sisibulala-ntsholongwane se-aminoglycoside kunye ne-calcium channel protein inhibitor. I-Neomycin sulfate ikwabophelela kwiprokaryotic ribosomes inqanda uguqulo kwaye iyasebenza ngokuchasene neebhaktheriya ezinegram-positive kunye negram-negative. I-Neomycin sulfate inhibits PLC (Phospholipase C) ngokubophelela kwi-inositol phospholipids. Kwakhona inqanda umsebenzi we-phosphatidylcholine-PLD kwaye ibangela ukuhlanganiswa kwe-Ca2 + kunye nokusebenza kwe-PLA2 kwiiplatelets zabantu. I-Neomycin sulfate inqanda i-DNase I eyenzelwe ukuthotywa kwe-DNA. Isetyenziselwa ukuthintela okanye ukunyanga izifo zolusu ezibangelwa yintsholongwane. Ayisebenzi ngokuchasene nosulelo lomngundo okanye lwentsholongwane.
Isicelo
I-Neomycin sulfate sisibulali-zintsholongwane se-aminoglycoside esiveliswe yi-S. fradiae esithintela ukuguqulelwa kweprotheyini ngokuzibophelela kwi-subunit encinci ye-prokaryotic ribosomes. Ivimba i-voltage-sensitive Ca2+ channels kwaye iyi-inhibitor enamandla yokukhululwa kwe-skeletal muscle sarcoplasmic reticulum Ca2 +. I-NEOMYCIN SULFATE iboniswe ukuba inqanda i-inositol phospholipid, i-phospholipase C, kunye nomsebenzi we-phosphatidylcholine-phospholipase D (IC50 = 65 μM). Isebenza kakhulu ngokuchasene ne-Gram-positive kunye ne-Gram-negative bacteria kwaye iqhele ukusetyenziselwa ukuthintela ukungcoliseka kwebhaktiriya kwiinkcubeko zeeseli.
