Inkcazelo emfutshane:
Inombolo ye-CAS: 23541-50-6
Ifomula yemolekyuli: C27H30ClNO10
Ubunzima bemolekyuli: 563.98
Ubume bekhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | I-Daunorubicin hydrochloride |
| Inombolo yeCAS. | 23541-50-6 |
| Umbala | Ubomvu ukuya kubomvu obunzulu |
| Ifom | Iqinile |
| Uzinzo: | Uzinzo |
| Ukunyibilika | Inyibilika simahla emanzini nakwi-methanol, inyibilika kancinane etywaleni, ayinyibiliki kwi-acetone. |
| Ukunyibilika kwamanzi | Inyibilika emanzini (50 mM) |
| Ugcino | Umoya ongaphakathi,2-8°C |
| Beka ubomi kwishelufa | 2 Yiindlebe |
| Iphakheji | 25kg/Igubu |
Ingcaciso yeMveliso
I-Daunorubicin hydrochloride (23541-50-6) yi-antitumor antibiotic esetyenziselwa unyango lwe-acute myeloid leukemias.1?Yenza umonakalo we-DNA ngokudibanisa.2?Yenza i-apoptosis kwiindidi zemigca yeseli.3?Ukuvinjelwa kwe-autophagy nge-chloroquine kwandisa i-daunorubicin -i-apoptosis eyenziwe kwiiseli ze-K562
Isicelo
I-Daunorubicin hydrochloride liyeza le-chemotherapy elisetyenziselwa ukunyanga iintlobo ezithile ze-leukemia kunye nezinye ii-cancer. Kukwiklasi yamachiza eyaziwa ngokuba yi-anthracyclines kwaye isebenza ngokuphazamisa ukukhula kunye nokusasazeka kweeseli zomhlaza emzimbeni.
I-Daunorubicin hydrochloride ngokuqhelekileyo ilawulwa nge-intravenously yingcali yezempilo kwimeko yeklinikhi. Idosi kunye nokuphindaphindwa konyango kuya kuxhomekeka kuhlobo oluthile lomhlaza onyangwayo, kunye nempilo yonke yesigulana kunye nempendulo yomntu ngamnye kwiyeza.
Kubalulekile ukulandela ngokucophelela imiyalelo yomboneleli wezempilo wokufumana i-daunorubicin hydrochloride kunye nokuya kuzo zonke izithuba ezicwangcisiweyo zokubeka iliso kunye nokuvavanya ngexesha lonyango. Eli yeza linokuba neziphumo ebezingalindelekanga ezimandundu, kwaye izigulane kufuneka zinxibelelane naziphi na iinkxalabo okanye utshintsho kwimeko yazo kwiqela labo lokhathalelo lwempilo.
Iziphumo eziqhelekileyo zecala ze-daunorubicin hydrochloride zingabandakanya isicaphucaphu, ukuhlanza, ukulahleka kweenwele, kunye nokunyuka kokungenwa kwezifo. Iziphumo ezibi kakhulu ezifana neengxaki zentliziyo kunye nokunyanzeliswa komongo wethambo nazo zingenzeka kwaye zifuna unyango olukhawulezileyo.
Njengawo onke amayeza e-chemotherapy, i-daunorubicin hydrochloride kufuneka isetyenziswe kuphela phantsi kweliso lengcali yezempilo enamava ekusebenziseni amayeza okunyanga umhlaza. Kubalulekile ukuxoxa ngazo naziphi na iimeko zonyango ezikhoyo okanye amayeza kunye nomboneleli wezempilo ngaphambi kokuba uqale unyango nge-daunorubicin hydrochloride.
