Inkcazelo emfutshane:
Inombolo ye-CAS: 38821-53-3
Ifomula yemolekyuli: C16H19N3O4S
ubunzima bemolekyuli: 349.4
Ubume bekhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Cefradine |
| Uzinzo | Ukukhanya okunovelwano |
| Imbonakalo | Umgubo omhlophe |
| Isivavanyi | 99% |
| Indawo yokunyibilika | 140-142 C |
| Ukupakisha | 5KG;1KG |
| Indawo yokubilisa | 898℃ |
Inkcazo
I-Cefradine (eyaziwa ngokuba yi-cephradine), 7- [D-2-amino-2 (1,4cyclohexadien1-yl) acetamido] -3-methyl-8-0x0-5thia-l-azabicyclo [4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 is a semi-synthetic cephalosporin antibiotic. isetyenziswa ngomlomo, intramuscularly, and intravenously. Ulwakhiwo lwecephradine luyafana nelo lwe cephalexin, umahluko kuphela kwiringi enamalungu amathandathu. ICephalexin inamalungu amathathu amathathu. iibhondi ezimbini ezenza inkqubo enuka kamnandi ngelixa i-cephradine inezibophelelo ezimbini kwindandatho efanayo[1].
Umzobo1 ubume bekhemikhali becefradine;
I-Cephradine i-white crystalline powder kunye ne-molecular weight of 349.4[2]. I-synthesis ye-cephradine ixoxiwe[3]. I-Cephradine inyibilika ngokukhululekileyo kwii-solvents ezinamanzi. Yi-zwitterion, equlathe zombini iqela le-alkaline amino kunye neqela le-acidic carboxyl. Kuluhlu lwe-pH lwe-3-7, i-cephradine ikhona njengetyuwa yangaphakathi[4]. I-Cephradine izinzile kwi-24 hr kwi-25 "ngaphakathi kwe-pH ye-2-8. Ekubeni izinzile kwimidiya ye-acidic, kukho ukulahleka okuncinci komsebenzi kwi-gastric fluid; ilahleko engaphantsi kwe-7% ixeliwe.[5].
I-Cephradine ibotshelelwe ngokubuthathaka kwiiprotheni ze-serum yabantu. Ichiza lalingaphantsi kwe-20% ebotshelelwe kwiiprotheni ze-serum[4]. Kwi-concentration ye-serum ye-10-12 pg / ml, i-6% yeyeza lilonke lalikwi-protein-bound bound complex. Esinye isifundo[6]ifumene ukuba kwi-concentration ye-10 pg / ml, i-28% yeziyobisi yayikwimeko yeprotheni; kwi-concentration ye-100 pg / ml, i-30% yeziyobisi yayikwimeko ebophelelwe yiprotheni. Olu phononongo lukwabonise ukuba ukongezwa kwe-serum kwi-cephradine kunciphisa umsebenzi we-antibiotic. Esinye isifundo[2]ibonise ukuba iprotheni ebophelelayo ye-cephradine yahluka ukusuka kwi-8 ukuya kwi-20%, kuxhomekeke kugxininiso lwechiza. Nangona kunjalo, uphando olwenziwa nguGadebusch et al.[5]akukho tshintsho kwi-MIC ye-cephradine ukuya nokuba yi-Staphylococcus aureus okanye i-Escherichia coli emva kokongezwa kweserum yomntu.
Iimpawu
I-Cephradine iyasebenza kwi-vitro ngokuchasene ne-spectrum ebanzi ye-gram-positive kunye ne-gram-negative ibhaktheriya, kubandakanywa nezilwanyana ze-pathogenic ezizimeleyo kwiklinikhi; i-compound ibonakaliswe ukuba i-acid stable, kwaye ukongezwa kwe-serum yabantu kwaba nefuthe elincinci kwi-inhibitory concentration (MIC) yezinto ezithintekayo. Xa zinikwe ngomlomo okanye ngaphantsi kwezilwanyana ezosulelwe ngokuvavanywa ngeendlela ezahlukeneyo zebhaktheriya ye-pathogenic, i-cephradine inika ukhuseleko olusebenzayo.[16]. Kunyango lwezifo ezithathelwanayo, iimpendulo zeklinikhi ezanelisayo kunyango lwe-cephradine ziye zabikwa ngabaphandi abaninzi.[14, 15, 17-19].
