Inkcazelo emfutshane:
Inombolo ye-CAS: 27164-46-1
Ifomula yemolekyuli: C14H15N8NaO4S3
ubunzima bemolekyuli: 478.5
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Cefazolin ityuwa yesodium |
| Inombolo yeCAS. | 27164-46-1 |
| Imbonakalo | Mhlophe ukuya kwi-Off-Mhlophe icrystalline powder |
| IBanga | Pharma iBanga |
| Ugcino | Gcina kwindawo emnyama, umoya ongena ngaphakathi, 2-8°C |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Uzinzo | Izinzile, kodwa inokuba nobushushu - gcina kwiimeko ezipholileyo. Ingatshintsha ibala xa ukhanyiselwe - gcina ebumnyameni. Ayihambelani ne-oxidizing agents ezinamandla. |
| Iphakheji | 25kg/Igubu |
Ingcaciso yeMveliso
Isithinteli-ntsholongwane sesemi synthetic esine-cephalosporins kwimolekyuli ye-cephalosporins. Iguqulelwe njenge-Xianfeng mycin. yeka-β-I-Lactam antibiotics, ewe β- I-derivatives ye-7-aminocephalosporanic acid (7-ACA) kwi-lactam antibiotics ineendlela ezifanayo ze-bactericidal. Olu hlobo lweyeza lunokutshabalalisa udonga lweebhaktheriya kwaye lubabulale ngexesha lokuzala. Inempembelelo eyomeleleyo yokukhetha iibhaktheriya kwaye phantse akukho tyhefu ebantwini, kunye nezibonelelo ezinje nge-antibacterial spectrum ebanzi, isiphumo esinamandla sokulwa ne-antibacterial, ukuchasana nee-enzymes ze-penicillin, kunye nokusabela okuncinci kokungadibaniyo xa kuthelekiswa ne-penicillin. Ke isisithinteli-ntsholongwane esibalulekileyo esinenkuthalo ephezulu, ubuthi obuphantsi, kunye nesicelo seklinikhi esibanzi. Isizukulwana sokuqala i-cephalosporins yaphuhliswa ngaphambili, kunye nomsebenzi onamandla wokulwa neebhaktheriya xa kuthelekiswa neChemicalbook, i-antibacterial spectrum encinci, kunye neziphumo ezingcono zebhaktheriya ye-anti Gram kune-bacteria ye-Gram negative. Iveliswa yi-Staphylococcus aureus β- Lactamase izinzile kwaye inokuthintela ukuveliswa kwebhaktiriya e-negative β- Lactamases ayizinzanga kwaye isenokuveliswa ziibhaktiriya ezininzi zeGram negative β- Eyonakaliswe yilactamases. I-Cefazolin sodium yi-semisynthetic yokuqala ye-cephalosporin eneziphumo zokulwa ne-antibacterial kuzo zombini iibhaktheriya zegram-positive kunye negram-negative. Ngokuqhelekileyo isetyenziselwa ukusuleleka kwenkqubo yokuphefumula, inkqubo ye-urogenital, izicubu ezithambileyo zesikhumba, ithambo kunye nokudibanisa, kunye ne-biliary tract ebangelwa yibhaktheriya enobungozi, kunye ne-endocarditis, i-sepsis, i-pharyngeal kunye nosulelo lwendlebe. Inomsebenzi onamandla ngokuchasene neebhaktheriya zegram-positive ezifana ne-Staphylococcus aureus kunye ne-Streptococcus (ngaphandle kwe-Enterococcus), kwaye iphakamileyo kwi-cephalosporins yesibini yesizukulwana sesithathu.
Ukusetyenziswa kwemichiza
I-Cefazolin (i-Ancef, i-Kefzol) yenye yoluhlu lwe-semisyntheticcephalosporins apho umsebenzi we-C-3 we-acetoxy uye watshintshwa yi-heterocycle ene-thiol-apha, i-5-methyl-2-thio-1,3,4-thiadiazole. Ikwanayo neqela elingaqhelekanga le-tetrazolylacetyl acylating. I-Cefazolin yakhululwa kwi-1973 njengetyuwa yesodium enyibilikayo emanzini. Isebenza kuphela ngolawulo lwabazali.
I-Cefazolin ibonelela ngamanqanaba aphezulu e-serum, ukucocwa kancinci, kunye nesiqingatha sobomi obude kunesinye isizukulwana sokuqala secephalosporins. Imalunga ne-75% yeprotheyini ebotshelelwe kwi-inplasma, ixabiso eliphezulu kunezinye i-cephalosporins ezininzi. Uphononongo lwakwangoko kwi-vitro kunye nezonyango lubonisa ukuba i-cefazolin iyasebenza kakhulu ngokuchasene ne-Gram-negative bacilli kodwa ingasebenzi kangako kwi-Gram-positive cocci kune-cephalothin orcephaloridine. Amazinga okwenzeka kwe-thrombophlebitis elandela inaliti ye-intravenous kunye neentlungu kwindawo ye-intramuscularinjection zibonakala zisezantsi kwi-parenteralcephalosporins.
