Inkcazelo emfutshane:
Inombolo ye-CAS: 472-15-1
Ifomula yemolekyuli:C30H48O3
ubunzima bemolekyuli: 456.71
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Betulinic acid |
| IBanga | Ibakala le-Pharma |
| Imbonakalo | Imhlophe okanye imhlophe |
| Isivavanyi | 98% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/igubu |
| Imeko | Izinzile, kodwa igcina ipholile. Ayihambelani ne-oxidizing agents enamandla, i-calcium gluconate, i-barbiturates, i-magnesium sulfate, i-phenytoin, i-vitamin B ye-sodium yeqela. |
Inkcazo
I-Betulinic acid (472-15-1) yiLupane triterpenoid yendalo esuka kumthi we birch emhlophe (Betula pubescens). Ibangela i-apoptosis kwiindidi zemizila yeeseli.1 Ibangela ukuvuleka kwe-mitochondrial permeability transition pore.2 ?Isebenza njenge-chemosensitizer yonyango lwe-anticancer yeziyobisi kwi-chemoresistant colon cancer cell lines.3 I-Cell permeable.
Sebenzisa
I-Betulinic Acid yi-pentacyclic triterpenoid yendalo. I-Betulinic Acid ibonisa umsebenzi wokuchasa ukudumba kunye ne-HIV. I-Betulinic Acid ikhetha ngokukhetha i-apoptosis kwiiseli ze-tumor ngokuvula ngokuthe ngqo indlela ye-mitochondrial ye-apoptosis ngokusebenzisa i-p53- kunye ne-CD95-i-independent mechanism. I-Betulinic Acid ibonisa kwakhona umsebenzi we-agonist we-TGR5.
I-Betulinic acid (BetA) isetyenzisiwe:
1.ukuvavanya iziphumo zayo njenge-antiviral agent ngokuchasene ne-Dengue virus (DENV).
I-2.njenge-sterol yokulawula i-protein-binding protein (SREBP) inhibitor ukucinezela i-lipid metabolism kunye nokwanda kweeseli ezicacileyo ze-cell renal cell carcinoma (ccRCC).
3.njengonyango lokuvavanya iipropathi zayo zokuchasana ne-tumor ukuze zisebenze iseli kunye ne-apoptotic cell death assays kwiimodeli ezininzi ze-myeloma.
Uphando lwe-Anticancer
Le khompawundi yi-pentacyclic triterpene efunyenwe kwiintlobo ze-Betula kunye ne-Zizyphus, ebonisa i-cytotoxicity ekhethiweyo kwiiseli ze-melanoma zabantu (I-Shoeb2006). Ivelisa iintlobo ze-oksijini esebenzayo, isebenze i-MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, imodareyitha i-pro-growth transcriptionalactivators, imodareyitha umsebenzi we-aminopeptidase-N, kwaye ngaloo ndlela inducesapoptosis kwiiseli zomhlaza (Desai et al. 2008; Fulda 2008) .
Umsebenzi webhayoloji
I-triterpenoid yendalo ebonisa i-anti-HIV kunye nomsebenzi we-antitumor. Ibangela ukuveliswa kweentlobo ze-oxygen esebenzayo (ROS) kwaye isebenze i-NF- κ B. Ibonisa umsebenzi we-agonist we-TRG5 (EC 50 = 1.04 μ M).
Izenzo zeBiochem/physiol
I-Betulinic acid, i-pentacyclic triterpene, ikhetha ngokukhetha i-apoptosis kwiiseli ze-tumor ngokuvula ngokuthe ngqo indlela ye-mitochondrial ye-apoptosis ngokusebenzisa i-p53- kunye ne-CD95-i-independent mechanism.
