Inkcazelo emfutshane:
Inombolo yeCAS:590-63-6
Ifomula yemolekyuli:C7H17ClN2O2
ubunzima bemolekyuli:196.68
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Bethanechol |
| IBanga | Ibakala le-Pharma |
| Imbonakalo | umgubo omhlophe |
| Isivavanyi | 95% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/igubu |
| Imeko | Indawo epholileyo neyomileyo |
Inkcazo
I-Bethanechol yi-ester yokwenziwa ngokwesakhiwo kunye ne-pharmacologically enxulumene ne-acetylcholine. I-agonist ye-muscarinic ecothayo ene-hydrolyzed engenazo iziphumo ze-nicotinic, i-bethanechol isetyenziselwa ukunyusa ithoni ye-muscle egudileyo, njengakwiphecana le-GI emva kotyando lwesisu okanye ekugcinweni komchamo ngokungabikho komqobo. Inokubangela uxinzelelo lwegazi, utshintsho kwizinga lentliziyo, kunye ne-bronchial spasms.
I-Bethanechol i-agonist ye-muscarinic acetylcholine receptors kunye ne-IC50 ixabiso le-1,837, i-25, i-631, i-317, kunye ne-393 μM ye-M1-5, ngokulandelanayo, kwi-radioligand yokubopha i-assay usebenzisa iiseli ze-CHO ezibonisa i-receptors yabantu. Ivimbela ukunyuka kwe-M2-mediated kwi-cyclic AMP eyenziwa yi-isoproterenol kwi-guinea yengulube emathunjini amancinci (IC50 = 127 μM). I-Bethanechol inyusa ithoni ye-basal ye-porcine eyedwa ye-intravesical ureter (EC50 = 4.27 μM). Kwakhona kubangela ukukhutshwa kwamanzi kwi-ileum, i-duodenum, kunye ne-jejunum yeegundane ze-anesthetized xa ilawulwa kwi-dose ye-60 μg / kg. Iifomyula eziqulethe i-bethanechol zisetyenziselwe ukunyusa ukuchama kunye nokuphucula ithoni ye-muscle egudileyo kwindlela yesisu.
Ukusetyenziswa kweKlinikhi
Olona setyenziso luphambili lwe-bethanechol chloride kukuphumza ukugcinwa komchamo kunye nokuphazamiseka kwesisu emva kotyando.Ichiza lisetyenziswa ngomlomo nangenaliti engaphantsi. Akufuneki ukuba ilawulwe nge-intramuscular okanye intravenousinjection ngenxa yengozi evela kwi-cholinergic overstimulation kunye nokulahleka kwesenzo esikhethiweyo. Ulawulo olululo lwechiza lunxulunyaniswa nobutyhefu obuphantsi kwaye akukho ziphene zinzima. I-Bethanechol chloride kufuneka isetyenziswe ngononophelo kwizigulane ze-asthmatic; xa isetyenziselwa i-glaucoma, ivelisa iintloko ezibuhlungu zangaphambili ukusuka ekuxineni kwe-sphinctermuscle esweni kunye ne-ciliary muscle spasms. Ubude bentshukumo yiyure enye.
Amachiza ezilwanyana kunye noNyango
Kwiyeza lezilwanyana, i-bethanechol isetyenziselwa ukuvuselela ukuqhawuka kwesinyi kwizilwanyana ezincinci. Isenokusetyenziswa njenge-esophageal okanye i-GI stimulant, nangona i-metoclopramide kunye/ okanye i-neostigmine ubukhulu becala iyithathele endaweni yayo ukuze isetyenziswe.
