Inkcazelo emfutshane:
Inombolo yeCAS: 54965-21-8
Ifomula yemolekyuli: C12H15N3O2S
ubunzima bemolekyuli: 265.333
Ubume beKhemikhali:
Inkcazo
I-Albendazole (ALBENZA) yi-anthelmintic elawulwa ngomlomo ebanzi. Ithebhulethi ye-Albendazole ehlafunwayo ifakwe kuluhlu lwe-World Health Organisation (WHO) lwamayeza ayimfuneko njengeyeza le-anthelminthic kunye ne-antifilarial yamathumbu. Ithebhulethi ye-Albendazole yaphuhliswa yi-SmithKline Animal Health Laboratories kwaye yamkelwa yi-US Food and Drug Administration (FDA) kwi-1996.
I-Albendazole inamandla okubulala ngokupheleleyo amaqanda e-whipworm kunye ne-hookworm kunye nokubulala ngokuyinxenye amaqanda e-Ascaris; Isenokususa iintlobo ngeentlobo zeentshulube ze-nematodes ezihlala ngaphakathi kwemizimba yezilwanyana, kwaye zineziphumo ekususeni okanye ekubulaleni ngokuthe ngqo iintshulube zetapeworm kunye necysticercci. Ngaloo ndlela iluncedo kunyango lwe-hydatid kunye ne-nervous system (cysticercosis) ebangelwa yintsholongwane yengulube yehagu, kunye nokunyangwa kwe-hookworm, i-roundworm, i-pinworm, i-nematode trichinella, i-tapeworm, i-whipworm kunye ne-stercoralis nematode.
Pharmacodynamics
I-Albendazole luhlobo oluthile lwe-benzimidazole. I-metabolized ngokukhawuleza kwi-vivo kwi-sulfoxide, i-sulfone kunye ne-2-polyamine sulfone alcohol. Ingacinezela ngokukhethayo nangokungaguqukiyo ukuthathwa kweglucose kwi-intestinal nematodes, nto leyo ekhokelela ekuphelisweni kwe-glycogen engapheliyo yombungu; kwangaxeshanye, iphinda ithintele umsebenzi we-fumarate reductase, kwaye ngaloo ndlela ithintele ukuveliswa kwe-adenosine triphosphate, ekugqibeleni ibangele ukufa kwee-parasites.
Ngokufana ne-mebendazole, ngokubangela i-denaturation ye-cytoplasmic microtubules ye-intestinal parasites kunye nokubophelela kwi-tubulin, ibangela ukuvala ukuthuthwa kwe-intracellular, okubangela ukuqokelela kwe-Golgi endocrine particles; icytoplasm iyanyibilika ngokuthe ngcembe, nto leyo ebangela ukufa kokugqibela kwezifunxi-gazi.
Le mveliso inokubulala ngokupheleleyo amaqanda e-hookworm, amaqanda e-pinworm, amaqanda e-wool spin, amaqanda e-tapeworm kunye namaqanda e-cysticercosis abetha amaqanda kwaye ngokuyinxenye abulale amaqanda e-Ascaris.
Ukusetyenziswa okuqhelekileyo
IAlbendazole lichiza elisetyenziselwa ukunyanga izifo ezibangelwa zizifunxi-gazi. Inokunikwa ukunyanga isifo sobuchopho esinqabileyo (neurocysticercosis) okanye inokunikwa ukunyanga usulelo lwe-parasitic olubangela urhudo olubalulekileyo (microsporidiosis).
Ukusetyenziswa kweKlinikhi
I-Albendazole inomsebenzi omninzi ngokuchasene ne-nematodes yamathumbu kunye ne-cestodes, kunye ne-flukes yesibindi i-Opisthorchis sinensis, i-Opisthorchis viverrini, kunye ne-Clonorchis sinensis. Ikwasetyenziswe ngempumelelo ngokuchasene neGiardia lamblia. Isetyenziswa kakhulu kwihlabathi liphela ukunyanga usulelo lwe-intestinalnematode. Isebenza njengedosi enye yonyango lwe-ascariasis, usulelo lweHookworm lweHlabathi eLitsha neliDala, kunye ne-trichuriasis. Unyango lwedosi eninzi kunye ne-albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, kunye nesifo se-hydatid. Ukusebenza kwe-albendazole ngokuchasene ne-tapeworms (cestodes) ngokuqhelekileyo kuyaguquguquka kwaye akubonakalisi. Ikwasebenza kakuhle ekunyangeni i-cerebral kunye ne-spinal neurocysticercosis, ngakumbi xa inikwe i-dexamethasone.I-Albendazole iyacetyiswa kunyango lwe-gnathostomiasis.
