Inkcazelo emfutshane:
Inombolo ye-CAS: 55268-74-1
Ifomula yemolekyuli:C19H24N2O2
ubunzima bemolekyuli:312.41
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Praziquantel |
| IBanga | Ibakala le-Pharma |
| Imbonakalo | Imhlophe okanye iphantse imhlophe i-crystalline powder |
| Isivavanyi | 99% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/igubu |
| Uphawu | Inyibilika ngokukhululekileyo kwi-ethanol okanye kwi-dichloromethane. Inyibilika kancinane emanzini |
| Imeko | Itywinwe kwindawo eyomileyo, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C |
Inkcazo
I-Praziquantel (PZQ) yinto ephuma kwi-isoquinoline enoninzi lwemisebenzi yebhayoloji efumaneka kwi-levo enantiomer. Ikhompawundi ayinamsebenzi ngokuchasene ne-nematodes, kodwa isebenza kakhulu ngokuchasene ne-cestodes kunye ne-trematodes.
I-Pharmacology kunye nendlela yokusebenza
I-Praziquantel yikhompawundi yepyrazinoquinoline eyaphuhliswa ekuqaleni kunyango lweschistosomiasis kodwa ifunyenwe inomsebenzi omninzi we-anthelminthic. I-Praziquantel yi-racemate kodwa i-enantiomer ye-R (+) inoxanduva lomsebenzi wayo wokulwa neeparasite. Iyasebenza ngokuchasene ne trematodes (zonke iintlobo ze-Schistosoma ze-pathogenic emntwini, i-Paragonimus westermani, ne-Clonorchis sinensis) kunye ne-cestodes (i-Taenia saginata, i-Taenia solium, i-Hymenolepis nana kunye ne-Diphyllobothrium latum) .
Indlela yokusebenza yepraziquantel ayaziwa ngokucacileyo. I-Schistosomes ithatha iyeza ngokukhawuleza. Ukuthathwa kweziyobisi kulandelwa ngoko nangoko kukwanda kwemisipha ekhokelela ekuncipheni kwe-tetanic kunye nokucoca i-parasite tegument.
Iziphumo ze-muscular zeyeza zicingelwa ukuba zinoxanduva lokutshintshwa kwee-parasite ukusuka kwi-mesenteric veins ukuya kwisibindi kwi-vivo. Nangona kunjalo, utshintsho lwe-hepatic lubonakalisiwe ngobuninzi be-schistosomicides kwaye alunakho ukunika naluphi na ulwazi oluthile lwendlela yokusebenza yechiza. Iziphumo zovavanyo lwakutsha nje zicebise ukuba iziphumo ze-antischistosomal zechiza zihambelana nefuthe layo kwi-tegument kunokuba kwi-musculature.
Enye impembelelo ye-pharmacological yeyeza ibandakanya ukwanda kwe-membrane permeability kwi-cations, ngakumbi i-calcium.
Nangona kunjalo, indima yale mpembelelo kwipropati ye-anthelminthic yeziyobisi ayaziwa.
Isicelo
Luhlobo olubanzi lwechiza lokulwa nesi sifo. Ingasetyenziselwa unyango kunye nothintelo lwe-schistosomiasis, i-cysticercosis, i-paragonimiasis, isifo se-hydatid, i-fasciolopsiasis, isifo se-hydatid, kunye nosulelo lweentshulube.
Isenokusetyenziswa njenge-anthelmintic kwaye iyasebenza ekunyangeni i-nematodes yezilwanyana zesisu. Inokuxutywa kwifidi ukuze isetyenziswe.
Imveliso luhlobo lwechiza le-anthelmintic elisebenzayo ekuphatheni i-Schistosoma japonicum, i-Schistosoma mansoni kunye ne-Schistosoma haematobium, i-Clonorchis sinensis, i-Paragonimus westermani, i-fasciolopsis buski, i-tapeworms kunye ne-cysticercosis. Inesiphumo esinamandla sokubulala kwi-tapeworm kwaye sithetha nje sisebenza ngokugqibeleleyo phakathi kwechiza lokulwa neschistosomiasis.
Luhlobo lwechiza le-anthelmintics elisetyenziswa ikakhulu ukunyanga i-schistosomiasis. Ingasetyenziselwa ukunyanga iFahrenheit schistosomiasis, taeniasis, paragonimiasis, kunye necysticercosis.
