Inkcazelo emfutshane:
Inombolo ye-CAS: 15687-27-1
Ifomula yemolekyuli: C13H18O2
Ubunzima bemolekyuli: 206.28
Ubume bekhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Ibuprofen |
| Inombolo yeCAS. | 15687-27-1 |
| Umbala | Mhlophe ukuya kumhlophe |
| Ifom | Umgubo weCrystalline |
| Ukunyibilika | Ngokuqhelekileyo ayinyibiliki emanzini, inyibilika ngokukhululekileyo kwi-acetone, kwi-methanol nakwi-methylene chloride. Inyibilika kwizisombululo ezixubileyo zealkali hydroxides kunye necarbonates. |
| Ukunyibilika kwamanzi | enganyibilikiyo |
| Uzinzo | Izinzile. Ukutsha. Ayihambelani ne-oxidizing agents ezinamandla |
| Beka ubomi kwishelufa | 2 Yiindlebe |
| Iphakheji | 25kg/Igubu |
Inkcazo
II-buprofen yeye-non-steroidal anti-inflammatory analgesic. Ine-anti-inflammatory egqwesileyo, i-analgesic kunye ne-antipyretic effect kunye neempendulo ezingalunganga. Sele isetyenziswa kakhulu kwihlabathi, njengawona mayeza athengiswa kakhulu angakhutshwa ngugqirha. Yona, kunye ne-aspirin kunye ne-paracetamol zidweliswe njengeemveliso ezintathu eziphambili ze-antipyretic analgesics. Kwilizwe lethu, isetyenziswa ikakhulu ekuthomalaliseni iintlungu kunye ne-anti-rheumatism, njl njl. Inezicelo ezincinci kunyango lwengqele kunye nomkhuhlane xa kuthelekiswa neparacetamol kunye ne-aspirin. Kukho iinkampani ezininzi zoxubo-mayeza ezilungele ukuveliswa kwe-ibuprofen eTshayina. Kodwa uninzi lweentengiso zentengiso yasekhaya ye-ibuprofen zithathwe yiNkampani yaseTianjin Sino-US.
I-Ibuprofen yafunyanwa ngokubambisana nguDkt. Stewart Adams (kamva uba nguprofesa kwaye waphumelela i-Medal of the British Empire) kunye neqela lakhe eliquka uCoLinBurrows kunye noDkt John Nicholson. Injongo yophononongo lokuqala yayikukuphuhlisa "i-aspirin ephezulu" ukufumana enye indlela yonyango lwe-rheumatoid arthritis enokuthelekiswa ne-aspirin kodwa eneziphumo ezibi kakhulu. Kwezinye iziyobisi ezifana ne-phenylbutazone, inomngcipheko omkhulu wokubangela ukunyanzeliswa kwe-adrenal kunye nezinye iziganeko ezimbi ezifana nezilonda zesisu. U-Adams ugqibe ekubeni akhangele iyeza elinokumelana nesisu esilungileyo, elibaluleke kakhulu kuwo onke amachiza achasene nokudumba.
Iziyobisi zePhenyl acetate zivuse umdla wabantu. Nangona amanye ala machiza afunyaniswa ukuba asemngciphekweni wokubangela izilonda ezisekelwe kuvavanyo lwenja, i-Adams iyazi ukuba le nto inokubangelwa kubude besiqingatha sobomi bokukhutshwa kweziyobisi. Kule klasi yeziyobisi kukho i-compound - ibuprofen, enobomi obufutshane obufutshane, igcina iiyure ezi-2 kuphela. Phakathi kwamachiza angamanye ahloliweyo, nangona engasebenzi kakhulu, lelona likhuselekileyo. Ngo-1964, ibuprofen yaba yeyona ndlela ithembisayo ye-aspirin.
Iimpawu
Injongo eqhelekileyo ekuphuhliseni amayeza eentlungu kunye nokuvuvukala kuye kwadalwa iikhompawundi ezikwaziyo ukunyanga ukuvuvukala, umkhuhlane, kunye neentlungu ngaphandle kokuphazamisa eminye imisebenzi ye-physiological. Iintlungu eziqhelekileyo zokunciphisa intlungu, ezifana ne-aspirin kunye ne-ibuprofen, zivimbela zombini i-COX-1 kunye ne-COX-2. Ukucaciswa kweyeza ngokubhekiselele kwi-COX-1 ngokuchasene ne-COX-2 imisela ukuba kunokwenzeka kwimiphumo emibi. Amayeza aneenkcukacha ezithe ngqo kwi-COX-1 aya kuba namandla amakhulu okuvelisa iziphumo ezibi. Ngokuvala i-COX-1, i-nonselective pain relievers yonyusa ithuba leziphumo ebezingalindelekanga ezingathandekiyo, ngakumbi iingxaki zokugaya ukutya ezifana nezilonda zesisu kunye nokopha kwesisu. I-COX-2 inhibitors, efana ne-Vioxx kunye ne-Celebrex, i-COX-2 ekhethiweyo kwaye ayichaphazeli i-COX-1 kwiidosi ezimiselweyo. I-COX-2 inhibitors imiselwe ngokubanzi kwi-arthritis kunye nokunciphisa intlungu. Kwi-2004, i-Food and Drug Administration (FDA) yazisa ukuba ingozi eyongeziweyo yokuhlaselwa yintliziyo kunye ne-stroke idibene ne-COX-2 inhibitors ethile. Oku kukhokelele ekulumkiseni iilebhile kunye nokususwa ngokuzithandela kweemveliso emarikeni ngabavelisi bamachiza; umzekelo, i-Merck yathatha i-Vioxx kwimarike ngo-2004. Nangona ibuprofen inqanda zombini i-COX-1 kunye ne-COX-2, inamaxesha amaninzi ngokukodwa kwi-COX-2 xa kuthelekiswa ne-aspirin, ivelisa iziphumo ezincinci zesisu..
