Ukubonelela ngomgangatho olungileyo 99%Umgubo weAlbendazole ococekileyo, iMathiriyeli ekrwada yezilwanyana

Sixhomekeke kumandla obugcisa awomeleleyo kwaye sisoloko siyila ubugcisa obuntsonkothileyo ukwanelisa ibango loBonelelo loBulunga obuLungileyo 99%Umgubo ococekileyo weAlbendazole, iMathiriyeli ekrwada yeZilwanyana, Sihlala sijonge phambili ekwenzeni ubudlelwane bezoshishino obunempumelelo nabathengi abatsha emhlabeni jikelele.
Sixhomekeke kumandla obugcisa owomeleleyo kwaye sihlala sisenza itekhnoloji ephucukileyo ukwanelisa iimfunoChina Albendazole kunye Pharmaceutical Chemical, Inkampani yethu igubungela indawo ye-20, 000 yeemitha square. Sinabasebenzi abangaphezu kwama-200, iqela lobuchwephesha lobuchwephesha, amava eminyaka eli-15, umsebenzi ogqwesileyo, umgangatho ozinzileyo nothembekileyo, ixabiso elikhuphisanayo kunye nomthamo owaneleyo wemveliso, le yindlela esenza ngayo abathengi bethu bomelele. Ukuba unombuzo, khumbula ukuba ungalibazisi ukuqhagamshelana nathi.

Inkcazo

I-Albendazole (ALBENZA) yi-anthelmintic elawulwa ngomlomo ebanzi. Ithebhulethi ye-Albendazole ehlafunwayo ifakwe kuluhlu lwe-World Health Organisation (WHO) lwamayeza ayimfuneko njengeyeza le-anthelminthic kunye ne-antifilarial yamathumbu. Ithebhulethi ye-Albendazole yaphuhliswa yi-SmithKline Animal Health Laboratories kwaye yamkelwa yi-US Food and Drug Administration (FDA) kwi-1996.
I-Albendazole inamandla okubulala ngokupheleleyo amaqanda e-whipworm kunye ne-hookworm kunye nokubulala ngokuyinxenye amaqanda e-Ascaris; Isenokususa iintlobo ngeentlobo zeentshulube ze-nematodes ezihlala ngaphakathi kwemizimba yezilwanyana, kwaye zineziphumo ekususeni okanye ekubulaleni ngokuthe ngqo iintshulube zetapeworm kunye necysticercci. Ngaloo ndlela iluncedo kunyango lwe-hydatid kunye ne-nervous system (cysticercosis) ebangelwa yintsholongwane yengulube yehagu, kunye nokunyangwa kwe-hookworm, i-roundworm, i-pinworm, i-nematode trichinella, i-tapeworm, i-whipworm kunye ne-stercoralis nematode.

Pharmacodynamics

I-Albendazole luhlobo oluthile lwe-benzimidazole. I-metabolized ngokukhawuleza kwi-vivo kwi-sulfoxide, i-sulfone kunye ne-2-polyamine sulfone alcohol. Ingacinezela ngokukhethayo nangokungaguqukiyo ukuthathwa kweglucose kwi-intestinal nematodes, nto leyo ekhokelela ekuphelisweni kwe-glycogen engapheliyo yombungu; kwangaxeshanye, iphinda ithintele umsebenzi we-fumarate reductase, kwaye ngaloo ndlela ithintele ukuveliswa kwe-adenosine triphosphate, ekugqibeleni ibangele ukufa kwee-parasites.
Ngokufana ne-mebendazole, ngokubangela i-denaturation ye-cytoplasmic microtubules ye-intestinal parasites kunye nokubophelela kwi-tubulin, ibangela ukuvala ukuthuthwa kwe-intracellular, okubangela ukuqokelela kwe-Golgi endocrine particles; icytoplasm iyanyibilika ngokuthe ngcembe, nto leyo ebangela ukufa kokugqibela kwezifunxi-gazi.
Le mveliso inokubulala ngokupheleleyo amaqanda e-hookworm, amaqanda e-pinworm, amaqanda e-wool spin, amaqanda e-tapeworm kunye namaqanda e-cysticercosis abetha amaqanda kwaye ngokuyinxenye abulale amaqanda e-Ascaris.

Ukusetyenziswa okuqhelekileyo

IAlbendazole lichiza elisetyenziselwa ukunyanga izifo ezibangelwa zizifunxi-gazi. Inokunikwa ukunyanga isifo sobuchopho esinqabileyo (neurocysticercosis) okanye inokunikwa ukunyanga usulelo lwe-parasitic olubangela urhudo olubalulekileyo (microsporidiosis).

Ukusetyenziswa kweKlinikhi

I-Albendazole inomsebenzi omninzi ngokuchasene ne-nematodes yamathumbu kunye ne-cestodes, kunye ne-flukes yesibindi i-Opisthorchis sinensis, i-Opisthorchis viverrini, kunye ne-Clonorchis sinensis. Ikwasetyenziswe ngempumelelo ngokuchasene neGiardia lamblia. Isetyenziswa kakhulu kwihlabathi liphela ukunyanga usulelo lwe-intestinalnematode. Isebenza njengedosi enye yonyango lwe-ascariasis, usulelo lweHookworm lweHlabathi eLitsha neliDala, kunye ne-trichuriasis. Unyango lwedosi eninzi kunye ne-albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, kunye nesifo se-hydatid. Ukusebenza kwe-albendazole ngokuchasene ne-tapeworms (cestodes) ngokuqhelekileyo kuyaguquguquka kwaye akubonakalisi. Ikwasebenza kakuhle ekunyangeni i-cerebral kunye ne-spinal neurocysticercosis, ngakumbi xa inikwe i-dexamethasone.I-Albendazole iyacetyiswa kunyango lwe-gnathostomiasis.

Sixhomekeke kumandla obugcisa awomeleleyo kwaye sisoloko siyila ubugcisa obuntsonkothileyo ukwanelisa ibango loBonelelo loBulunga obuLungileyo 99%Umgubo ococekileyo weAlbendazole, iMathiriyeli ekrwada yeZilwanyana, Sihlala sijonge phambili ekwenzeni ubudlelwane bezoshishino obunempumelelo nabathengi abatsha emhlabeni jikelele.
Umgangatho olungileyoChina Albendazole kunye Pharmaceutical Chemical, Inkampani yethu igubungela indawo ye-20, 000 yeemitha square. Sinabasebenzi abangaphezu kwama-200, iqela lobuchwephesha lobuchwephesha, amava eminyaka eli-15, umsebenzi ogqwesileyo, umgangatho ozinzileyo nothembekileyo, ixabiso elikhuphisanayo kunye nomthamo owaneleyo wemveliso, le yindlela esenza ngayo abathengi bethu bomelele. Ukuba unombuzo, khumbula ukuba ungalibazisi ukuqhagamshelana nathi.