Icwecwe leFolate (i-Folic Acid, iVit B9)

Inkcazelo emfutshane:

Umjikelo, umbhoxo, umbhoxo, unxantathu, iDayimane kunye nezinye iimilo ezikhethekileyo zonke ziyafumaneka.

izatifikethi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ulwazi olusisiseko
Igama lemveliso	Iitafile zeFolate
Amanye amagama	Icwecwe leFolic Acid, iCwecwe yeFolate esebenzayo, icwecwe leFolic Acid esebenzayo, njl.
IBanga	Ibakala lokutya
Imbonakalo	Njengeemfuno zabathengi Umjikelo, umbhoxo, umbhoxo, unxantathu, iDayimane kunye nezinye iimilo ezikhethekileyo zonke ziyafumaneka.
Beka ubomi kwishelufa	I-2-3 iminyaka, ngokuxhomekeke kwimeko yevenkile
Ukupakisha	Ubuninzi, iibhotile, iipakethi zeblister okanye iimfuno zabathengi
Imeko	Gcina kwizikhongozeli eziqinileyo, ezikhuselwe ekukhanyeni.

Inkcazo

Iimpembelelo ze-folic acid kwizinto eziphilayo zibonakaliswa ngokukodwa kule miba ilandelayo: ukuthatha inxaxheba kwi-metabolism yezinto zofuzo kunye neprotheni; ichaphazela ukusebenza kokuzala kwezilwanyana; ichaphazela ukukhutshwa kwe-pancreas yezilwanyana; ukukhuthaza ukukhula kwezilwanyana; kunye nokuphucula ukhuselo lomzimba.

I-Methyltetrahydrofolate ngokuqhelekileyo ibhekisela kwi-5-methyltetrahydrofolate, enomsebenzi wokondla umzimba kunye nokuncedisa i-folic acid. I-5-Methyltetrahydrofolate yinto enemisebenzi esebenzayo eguqulwayo esuka kwi-folic acid ngokusebenzisa uchungechunge lwe-biochemical reactions emzimbeni womntu. Ingasetyenziswa ngokuthe ngqo ngumzimba kwiindlela ezahlukeneyo zemetabolism ukugcina ukusebenza okuqhelekileyo komzimba, ngaloo ndlela kudlala indima ekondleni umzimba.

Umsebenzi

I-Folic acid luhlobo lweevithamini B, eyaziwa ngokuba yi-pteroylglutamic acid. I-5-methyltetrahydrofolate yinyathelo lokugqibela kwi-metabolism kunye nenkqubo yokuguqulwa kwe-folic acid emzimbeni. Ngenxa yomsebenzi wayo osebenzayo, ikwabizwa ngokuba yi-active. I-Folic acid iyinxalenye ye-metabolic ye-folic acid emzimbeni.

Ngenxa yokuba i-molecular structure ye-5-methyltetrahydrofolate inokuthatyathwa ngokuthe ngqo ngumzimba ngaphandle kokwenza iinkqubo eziyinkimbinkimbi zokuguqulwa kwe-metabolic, ifumaneka ngokubanzi kwiiseli zomzimba. Xa kuthelekiswa ne-folic acid, kulula ukongeza izondlo zomzimba, ngakumbi kubasetyhini abafuna ukulungiselela ukukhulelwa kunye nabasetyhini abakhulelweyo ngexesha lokukhulelwa.

I-Folic acid yenye yeevithamini ezibalulekileyo ekukhuleni nasekuveliseni iiseli zomzimba. Ukusilela kwayo kuya kuchaphazela imisebenzi eqhelekileyo yomzimba womntu. Uncwadi oluninzi luye lwaxela ukuba ukunqongophala kwe-folic acid kuhambelana ngqo neziphene ze-neural tube, i-megaloblastic anemia, i-cleft lip kunye nenkalakahla, ukudakumba, amathumba kunye nezinye izifo.

Ukungasebenzi kakuhle kwetyhubhu ye-Neural (NTDs)

I-Neural tube malformations (NTDs) liqela leziphene ezibangelwa ukuvala okungaphelelanga kwe-neural tube ngexesha lokuphuhliswa kwe-embryonic, kubandakanywa i-anencephaly, i-encephalocele, i-spina bifida, njl., kwaye yenye yezona ziphene eziqhelekileyo ze-neonatal. Kwi-1991, iBhunga loPhando lwezoNyango lwaseBrithani liqinisekisile okokuqala ukuba ukuxhaswa kwe-folic acid ngaphambi nangemva kokukhulelwa kunokuthintela ukwenzeka kwe-NTD kunye nokunciphisa iziganeko nge-50-70%. Isiphumo sothintelo se-folic acid kwii-NTDs sithathwa njengenye yezona zinto zinomdla kakhulu zokufunyanwa kwezonyango ngasekupheleni kwenkulungwane yama-20.

I-Megaloblastic anemia (MA)

I-Megaloblastic anemia (MA) luhlobo lwe-anemia olubangelwa ukukhubazeka kwi-DNA synthesis ebangelwa ukungabikho kwe-folic acid okanye i-vitamin B12. Ixhaphake kakhulu kwiintsana kunye nabasetyhini abakhulelweyo. Ukukhula okuqhelekileyo komntwana ongekazalwa kufuna umthamo omkhulu wefolic acid reserves kumzimba kamama. Ukuba i-folic acid egciniweyo iyancipha ngexesha lokubeleka okanye kwangethuba emva kokubeleka, i-megaloblastic anemia iya kwenzeka kwi-fetus kunye nomama. Emva kokuncedisa nge-folic acid, isifo sinokubuyiselwa ngokukhawuleza kwaye siphiliswe.

Folic acid kunye nemilebe ecandekileyo kunye nenkalakahla

Umlebe kunye nenkalakahla ecandekileyo (CLP) sesinye seziphene ezixhaphakileyo ekuzalweni kwakho. Unobangela wokucandeka komlomo nenkalakahla awukacaci. Ukongezwa kwe-folic acid ngexesha lokukhulelwa kwangethuba kuye kwangqinwa ukuba kuthintele ukuzalwa kwabantwana abacandeke umlebe kunye nenkalakahla.

Ezinye izifo

Ukunqongophala kwe-folic acid kunokubangela ingozi enkulu koomama nakubantwana, njengokuphuphuma kwesisu okuqhelekileyo, ukuzalwa ngaphambi kwexesha, ubunzima bokuzala, ukungagayeki komntwana kunye nokungakhuli. Uninzi loncwadi lunika ingxelo yokuba isifo sika-Alzheimer, ukudakumba, kunye nokungahambi kakuhle kwemithambo-luvo kwiintsana ezisanda kuzalwa kunye nezinye izilonda zengqondo ezinxulumene nazo zonke zinxulumene nokunqongophala kwe-folic acid. Ukongeza, ukunqongophala kwe-folic acid kunokubangela amathumba (umhlaza wesibeleko, umhlaza we-bronchial, umhlaza wommizo, umhlaza wesisu, njl.njl.), i-atrophic gastritis engapheliyo, isifo se-colitis, isifo senhliziyo kunye nesifo se-cerebrovascular, kunye nezinye izifo ezifana ne-glossitis kunye ukukhula kakubi. Abantu abadala abangenalo i-folic acid kunye nokusela utywala ngokugqithiseleyo banokutshintsha isakhiwo se-mucosa yamathumbu abo.