Inkcazelo emfutshane:
Inombolo yeCAS:24729-96-2
Ifomula yemolekyuli:C18H34ClN2O8PS
ubunzima bemolekyuli: 504.96
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Clindamycin Phosphate |
| IBanga | Ibakala le-Pharma |
| Imbonakalo | umgubo omhlophe |
| Isivavanyi | 95% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/igubu |
| Imeko | Izinzile, kodwa igcina ipholile. Ayihambelani ne-oxidizing agents enamandla, i-calcium gluconate, i-barbiturates, i-magnesium sulfate, i-phenytoin, i-vitamin B ye-sodium yeqela. |
Inkcazo
I-Clindamycin phosphate yi-ester enyibilikayo emanzini ye-antibiotic ye-semisynthetic eveliswa yi-7 (S) -chloro-substitution ye-7 (R) -i-hydroxyl iqela le-antibiotic yomzali, i-lincomycin. Iphuma kwi-lincomycin (i-lincosamide). Inesenzo esiphambili se-bacteriostatic ngokuchasene ne-Gram-positive aerobes kunye noluhlu olubanzi lwee-anaerobicbacteria. Yeyona ntsholongwane isetyenziswa kunyango losulelo. Oku kunokubandakanya usulelo lwendlela yokuphefumla, i-septicaemia, i-peritonitis kunye nosulelo lwamathambo. Ikwasetyenziselwa ukunyanga i-acne ephakathi ukuya kwi-acne.
Sebenzisa
I-Clindamycin phosphate isetyenziswa ngokwesihloko yodwa okanye idibene ne-benzoyl peroxide kunyango lwe-acne vulgaris evuthayo. Xa kuvavanywa iingenelo ezinokuthi zibe kho zonyango lwe-clindamycin, ukuba nokwenzeka kweziphumo ezibi kakhulu ze-GI ezinxulumene nechiza kufuneka kuqwalaselwe. Unyango lwe-acne vulgaris kufuneka lube lomntu ngamnye kwaye lutshintshwe rhoqo ngokuxhomekeke kwiindidi zezilonda ezixhaphakileyo kunye nempendulo kunyango. I-anti-infectives ye-topical, kuquka i-clindamycin, isebenza ngokubanzi kunyango lwe-acne evuthayo ephakathi. Nangona kunjalo, ukusetyenziswa kwe-topical anti-infectives njenge-monotherapy kunokukhokelela ekuchaseni ibhaktheriya; oku kuxhathisa kunxulunyaniswa nokuncipha kokusebenza kakuhle kwezonyango.I-clindamycin yesihloko iluncedo ngakumbi xa isetyenziswa ne-benzoyl peroxide okanye i-topical retinoids. Iziphumo zezifundo zeklinikhi zibonisa ukuba unyango oludibeneyo lukhokelela ekunciphiseni inani le-lesion epheleleyo ye-50-70%.
I-Clindamycin 2-phosphate yityuwa ye-clincamycin, i-semi-synthetic lincosamide. Ityuwa ilungiselelwe yi-phosphorylation ekhethiweyo ye-2-hydroxy moiety yeswekile ye-clindamycin. Ukwaziswa kwephosphate kunceda ukunyibilika okuphuculweyo kumayeza atofwayo. Njengamanye amalungu osapho lwe-lincosamide, i-clindamycin 2-phosphate sisithinteli-ntsholongwane esibanzi esinomsebenzi ochasene neebhaktheriya ze-anaerobic kunye neeprotozoans. I-Clindamycin isebenza ngokuzibophelela kwi-23S ribosomal subunit, inqanda ukuhlanganiswa kweprotheyini.
