Inkcazelo emfutshane:
Inombolo ye-CAS: 50-78-2
Ifomula yemolekyuli:C9H8O4
ubunzima bemolekyuli: 180.16
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Amanye amagama | Acetylsalicylic acid |
| Igama lemveliso | I-Aspirin |
| IBanga | IBanga lePharma / iBanga lokutyisa |
| Imbonakalo | Umgubo omhlophe wekristale |
| Isivavanyi | 99% |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Uphawu | I-soluble kancinane emanzini, i-soluble ethanol, i-ethyl ether, i-chloroform, isisombululo se-sodium hydroxide kunye nesisombululo se-sodium carbonate. |
| Ugcino | Gcina kwindawo epholileyo eyomileyo |
Ingcaciso yeMveliso
I-Aspirin, ekwaziwa ngokuba yi-acetylsalicylic acid (ASA), liyeza elisetyenziselwa ukunciphisa iintlungu, umkhuhlane, okanye ukudumba.Iimeko ezithile ezivuthayo ezisetyenziselwa ukunyanga i-aspirin ibandakanya isifo se-Kawasaki, i-pericarditis, kunye ne-rheumatic fever. I-Aspirin lelona yeza lisetyenziswa kakhulu kwihlabathi.
Umsebenzi
I-Acetylsalicylic acid ine-antipyretic analgesic, i-anti-inflammatory kunye ne-anti-rheumatism effect, yiloo nto isetyenziswa rhoqo kwi-fiva, intloko ebuhlungu, iintlungu zemisipha, i-neuralgia, i-rheumatic fever, isifo samathambo, i-gout, njl. Kananjalo ine-antiplatelet aggregation effect, kwaye ingasetyenziselwa uthintelo lwe-arterial thrombosis, atherosclerosis, ischemia ye-cerebral edlulayo kunye ne-myocardial infarction; Ukongeza, i-acetylsalicylic acid ingasetyenziselwa kunyango lwesifo se-biliary roundworm kunye nonyawo lomdlali.
Izenzo ze-Pharmacological
I-Acetylsalicylic acid yenye ye-antipyretic analgesics yendabuko, kunye nendima yokuhlanganiswa kweplatelet. I-Acetylsalicylic acid emzimbeni ineempawu ze-antithrombotic, inokunciphisa ukubunjwa kwe-blood clots ephazamisayo kwi-artery ejikelezileyo, kwaye inqanda ukukhululwa kwempendulo yeplatelet kunye ne-ADP engapheliyo, i-5-HT, njl., ngoko ke ukuvimbela isigaba sesibini ngaphandle kweyokuqala isigaba sokudityaniswa kweplatelet. Indlela yokusebenza ye-acetylsalicylic acid kukwenza iiplatelet cyclooxygenase acetylation, ngaloo ndlela inqanda ukubunjwa kwe-peroxide yeringi, kunye nokwakheka kwe-TXA2 kuncitshiswe kwakhona. Ngelo xesha yenza i-platelet membrane protein acetylation, kwaye inhibit i-enzyme ye-membrane yeplatelet, enceda ukuvimbela umsebenzi weplatelet. Njengoko i-cyclooxygenase inhibited, ichaphazela udonga lwegazi oludityanisiweyo ukuba lube yi-PGI2, i-platelet TXA2 i-enzymes yokwenziwa kwakhona kufuneka ivinjwe; ke iya kuba nefuthe ekwenziweni kwazo zombini i-TXA2 kunye ne-PGI2 xa iidosi ezinkulu. Ifanelekile kwisifo senhliziyo ye-ischemic, emva kwe-percutaneous transluminal coronary angioplasty okanye i-coronary artery bypass grafting, ukukhusela i-ischemic stroke, i-myocardial infarction kunye nokunciphisa iziganeko ze-arrhythmia. I-Acetylsalicylic acid nayo ingasetyenziswa kunyango lwesifo se-biliary roundworm kunye nonyawo lomdlali.
Isicelo
Yeyona nto isetyenzisiweyo, eyona nto idumileyo kunye neyona ndlela ixhaphakileyo ye-antipyretic analgesics anti-rheumatism iyeza, inemiba yeziphumo ze-pharmacological njenge-antipyretic-analgesic kunye ne-anti-inflammatory, anti-platelet aggregation kwaye isebenza ngokukhawuleza nangempumelelo. I-overdosage inokufunyaniswa ngokulula kwaye inyangwe, kunye neentshukumo ezinqabileyo zokungalungelani. Ihlala isetyenziselwa umkhuhlane obandayo, intloko ebuhlungu, i-neuralgia, i-joint pain, i-rheumatic fever, isifo samathambo esinamandla sesondo, isifo samathambo kunye namazinyo, njl njl. I-acetylsalicylic acid isebenza njengendawo ephakathi kwamanye amayeza.
