Inkcazelo emfutshane:
Inombolo yeCAS: 7177-48-2
Ifomula yemolekyuli:C16H25N3O7S
ubunzima bemolekyuli: 403.45
Ubume beKhemikhali:
| Ulwazi olusisiseko | |
| Igama lemveliso | Ampicillin |
| IBanga | IBanga lezamayeza |
| Imbonakalo | Imhlophe okanye iphantse imhlophe, i-crystalline powder |
| Isivavanyi | |
| Beka ubomi kwishelufa | iminyaka eyi-2 |
| Ukupakisha | 25kg/igubu |
| Imeko | igcinwe kwindawo epholileyo neyomileyo |
Inkcazo
Njengeqela le-penicillin ye-beta-lactam antibiotics, i-Ampicillin yi-penicillin yokuqala ebanzi, enomsebenzi we-vitro ngokuchasene ne-Gram-positive kunye ne-Gram-negative aerobic kunye nebhaktiriya ye-anaerobic, edla ngokusetyenziselwa ukuthintela kunye nokunyanga usulelo lwebhaktiriya kwindlela yokuphefumla, umchamo. iphecana, indlebe ephakathi, izono, isisu kunye namathumbu, isinyi, kunye nezintso, njl. ezibangelwa ziibhaktheriya ezithintekayo. Ikwasetyenziselwa ukunyanga i-gonorrhea engantsonkothanga, i-meningitis, i-endocarditis salmonellosis, kunye nolunye usulelo olubi ngokulawulwa ngomlomo, inaliti ye-intramuscular okanye nge-intravenous infusion. Njengazo zonke ii-antibiotics, ayisebenzi kunyango losulelo lwentsholongwane.
I-Ampicillin isebenza ngokubulala iibhaktheriya okanye ukuthintela ukukhula kwazo. Emva kokungena kwiibhaktheriya ze-Gram-positive kunye ne-Gram-negative, isebenza njenge-inhibitor engenakunqandwa ye-enzyme transpeptidase efunekayo kwiibhaktheriya ukwenza udonga lweseli, oluphumela ekuvinjweni kwe-cell wall synthesis kwaye ekugqibeleni ikhokelela kwi-cell lysis.
Umsebenzi we-Antimicrobial
I-Ampicillin ayisebenzi kancinci kune-benzylpenicillin ngokuchasene neebhaktheriya ezininzi ezineGram-positive kodwa isebenza ngakumbi kwi-E. faecalis. I-MRSA kunye neentlobo zeStr. I-pneumoniae enokungenwa lula kwi-benzylpenicillin iyaxhathisa. Uninzi lweqela D streptococci, anaerobic Gram-positive cocci kunye bacilli, kuquka L. monocytogenes, Actinomyces spp. kunye neArachnia spp., zisesichengeni. I-Mycobacteria kunye ne-nocardia zixhathisa.
I-Ampicillin inomsebenzi ofanayo ne-benzylpenicillin ngokuchasene ne-N. gonorrhoeae, N. meningitidis kunye ne-Mor. i-catarrhalis. Isebenza ngamaxesha angama-2-8 ngaphezu kwe-benzylpenicillin ngokuchasene ne-H. influenzae kunye ne-Enterobacteriaceae ezininzi, kodwa iintlobo ezivelisa i-β-lactamase zixhathisa. Pseudomonas spp. zixhathisa, kodwa iBordetella, iBrucella, iLegionella kunye neCampylobacter spp. badla ngokuba sesichengeni. Ezinye ii-anaerobes ze-Gram-negative ezifana ne-Prevotella melaninogenica kunye ne-Fusobacterium spp. zichaphazeleka, kodwa B. fragilis iyaxhathisa, njengoko kunjalo mycoplasmas kunye rickettsiae.
Umsebenzi ochasene neklasi ye-molecular A β-lactamase-producing strains of staphylococci, gonococci, H. influenzae, Mor. i-catarrhalis, i-Enterobacteriaceae ethile kunye ne-B. fragilis yongezwa kubukho be-β-lactamase inhibitors, ngokukodwa i-clavulanic acid.
Umsebenzi wayo we-bactericidal ufana ne-benzylpenicillin. Ukudibana kwe-bactericidal kwenzeka kunye ne-aminoglycosides ngokuchasene ne-E. faecalis kunye nee-enterobacteria ezininzi, kunye ne-mecillinam ngokuchasene nenani le-enterobacteria ekwazi ukumelana ne-ampicillin.
